RON手术存在导致眼球穿破、视网膜脱离等严重并发症的可能性，按医学伦理学的概念，这些引起视力丧失的高风险并发症发生的几率应控制在多大才算是可以接受的治疗方案呢？CRVO的晚期并发症，如玻璃体出血、虹膜新生血管等将直接影响RON的术后效果，提示病程和手术时机的选择可能对治疗预后有一定影响。同时，视力评价方式的不同也是一个影响因素[20]。
总之，在CRVO还没有有效的治疗方法以前，进一步的科学性探索是必须的。但是，鉴于RON手术机制还存在较大的争议，患者的视力预后与自然病程比较没有统计学的差异，而且手术风险较大，故临床医生应慎重考虑该手术的实施。对RON手术有效性的评价，最终取决于随机对照的临床实验结果。同时，应遵循医学伦理道德的规范，做到患者知情同意。
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