本研究发现，冠心病组患者血浆vWF水平均高于健康对照组，提示冠状动脉粥样硬化病变患者血管内皮细胞受损并存在血小板活性的增强［5］。冠心病患者血浆vWF水平与冠脉狭窄程度呈显著正相关，冠状动脉狭窄程度越重，血浆vWF水平越高。冠心病组患者按冠状动脉A、B、C 3型病变vWF水平逐渐依次增高，提示随冠状动脉病变程度的逐级加重，血管内皮受损范围扩大和程度加重，管壁不光滑，造成了更多血小板激活、黏附，甚至血栓形成，发生梗死的危险度逐级增高，需及早积极治疗，防止病情进展及急性冠状动脉事件的发生；同时也提示血浆vWF水平测定可作为评估冠状动脉病变严重程度及血栓形成危险的有效手段。
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