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舒张性心力衰竭(下)
周京敏 蔡逎绳
http://www.healthoo.com 2003年1月30日
(四)瓣膜病
长期压力或容量负荷过重会导致心肌呈向心性或离心性肥厚,引起舒张功能不全。长期容量负荷过重,如二尖瓣返流和主动脉瓣返流会引起舒张末室壁张力增加,左心室呈离心性肥厚;长期严重的压力负荷过重,如主动脉瓣狭窄,会引起收缩末压力升高,产生向心性心肌肥厚。两种类型的心肌肥厚,均伴有舒张功能受损,而心室僵硬度增加仅在向心性肥厚时增加,在离心性肥厚时下降。研究发现约50%的主动脉瓣返流患者和约90%的主动脉瓣狭窄患者即使收缩功能正常,也会有左室舒张异常,表现为舒张时间延长、心肌僵硬度增加。因而,舒张功能异常的出现早于收缩功能异常,是充血性心衰的早期阶段。瓣膜性心脏病的最早症状,如劳力性呼吸困难和最大氧耗降低通常是由舒张功能异常引起的。同样也有研究发现,换瓣术后,即使左室心肌重量、左室射血分数恢复正常,舒张功能异常也会持续数年之久[22]。
(五)其他
各种病因引起的心肌肥厚,限制性心肌疾病,如淀粉样变、心内膜下弹力纤维增生、糖尿病心肌病变等都可致舒张性心衰。心房颤动,尤其是心室率增快时,心时充盈时间明显缩短也可表现为舒张性心衰。
六、诊断
舒张性心衰的诊断较为困难,因为仅仅依靠病史,体格检查,心电图和胸片很难做出舒张性心衰的诊断,而且很难和收缩性心衰相鉴别。
目前诊断舒张性心衰尚无统一的标准,临床较多采用的是1998年欧洲心脏学会心衰研究组提出的建议[19]。该建议认为,诊断舒张性心衰需要同时满足三个必须条件:1. 有充血性心衰的症状或体征;2. 左室收缩功能正常或轻度异常;3. 左室舒张、充盈、舒张期扩张、僵硬度不正常。
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